The player is able to complete side missions away from the main story to unlock additional content and collectible items.

Spider-Man can freely move around New York City, interacting with characters and undertaking missions, and unlocking new gadgets and suits by progressing through the main story or completing tasks. The game is presented from the third-person perspective with a primary focus on Spider-Man's traversal and combat abilities.

Released in three distinct chapters, The Heist, Turf Wars, and Silver Lining, the DLC serves as an epilogue to the main game taking place three months following its conclusion and follows Spider-Man as he contends with a new crime wave led by the physically enhanced mob boss Hammerhead. Based on the Marvel Comics superhero Spider-Man, it is inspired by the character's long-running comic book mythology and adaptations in other media. Marvel's Spider-Man: The City That Never Sleeps is a collection of downloadable content (DLC) developed by Insomniac Games and published by Sony Interactive Entertainment for the 2018 video game Marvel's Spider-Man.

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